Protease inhibition as new therapeutic strategy for GI diseases

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Protease inhibition as new therapeutic strategy for GI diseases

The GI tract is the most exposed organ to proteases, both in physiological and pathophysiological conditions. For digestive purposes, the lumen of the upper GI tract contains large amounts of pancreatic proteases, but studies have also demonstrated increased proteolytic activity into mucosal tissues (both in the upper and lower GI tract), associated with pathological conditions. This review aim...

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ژورنال

عنوان ژورنال: Gut

سال: 2016

ISSN: 0017-5749,1468-3288

DOI: 10.1136/gutjnl-2015-309147